Just a list of resources for now. Will structure later.
Blocking Glycolysis May Be A Treatment For Lupus. haidut - Feb 12, 2015 https://raypeatforum.com/community/threads/blocking-glycolysis-may-be-a-treatment-for-lupus.5865/
"Natural" Gut Flora May Cause Multiple Sclerosis (MS) and Lupus - May 6, 2016 https://raypeatforum.com/community/threads/natural-gut-flora-may-cause-multiple-sclerosis-ms-and-lupus.10919/
A Common Probiotic Strain (lactobacillus) May Cause Lupus. haidut - Jan 3, 2019 https://raypeatforum.com/community/threads/a-common-probiotic-strain-lactobacillus-may-cause-lupus.27085/
Estrogen Can Both Cause And Exacerbate Lupus. haidut - Nov 3, 2020 https://raypeatforum.com/community/threads/estrogen-can-both-cause-and-exacerbate-lupus.37141/
K.M. Stevens has argued that while rheumatic fever and glomerulonephritis are caused by the antigens of streptococci, systemic lupus erythematosis (SLE) is probably caused by the antigens of gram-positive lactobacilli found in the normal flora. K.M. Stevens, The aetiology of SLE, Lancet, Sept. 5, 506-508, 1964. https://wiki.chadnet.org/food-junk-and-some-mystery-ailments-fatigue-alzheimers-colitis-immunodeficiency
"Since the 1950s, it has been recognized that antibodies produced by B cells are central to the autoimmune process. With aging and stress, the regulatory thymus gland shrinks (from about 3 5 grams around puberty to about 5 grams at age 70), while the more stable B cells are maintained at about the same level, or even increased. Without a 4 functioning thymus, the antibodies bound to antigenic material become a problem (for example activating mast cells and platelets), rather than being just part of a corrective process." From Arthritis, Autoimmunity, & Aging article by Ray https://wiki.chadnet.org/arthritis-autoimmunity-and-aging.pdf
https://wiki.chadnet.org/immunodeficiency-dioxins-stress-and-the-hormones
"People who have autoimmune diseases such as lupus and Sjogrens syndrome (which are promoted by estrogen: Ahmed and Talal) have antibodies which sometimes react positively in the AIDS test, and searches for the HIV virus in such people have found no evidence of it. (Nelson, et al., 1994; Deas, et al., 1998.)"
Estrogen Induces Thymic Atrophy by Eliminating Early Thymic Progenitors and Inhibiting Proliferation of β-Selected Thymocytes "This paper talks about how administration of estradiol can induce thymic atrophy and ultimately lead to lupus since most SLE patients have a smaller thymus than the controls" https://doi.org/10.4049/jimmunol.176.12.7371
“Emerging evidence supports that mitochondrial dysfunction contributes to systemic lupus erythematosus (SLE) pathogenesis. Here we show that programmed mitochondrial removal, a hallmark of mammalian erythropoiesis, is defective in SLE. Specifically, we demonstrate that during human erythroid cell maturation, a hypoxia-inducible factor (HIF)-mediated metabolic switch is responsible for the activation of the ubiquitin-proteasome system (UPS), which precedes and is necessary for the autophagic removal of mitochondria. A defect in this pathway leads to accumulation of red blood cells (RBCs) carrying mitochondria (Mito+ RBCs) in SLE patients and in correlation with disease activity. Antibody-mediated internalization of Mito+ RBCs induces type I interferon (IFN) production through activation of cGAS in macrophages. Accordingly, SLE patients carrying both Mito+ RBCs and opsonizing antibodies display the highest levels of blood IFN-stimulated gene (ISG) signatures, a distinctive feature of SLE.” https://doi.org/10.1016/j.cell.2021.07.021
One Radio Network - 19.12.17 The Nation's Top Contrarian on Health Ray discusses a woman's lupus going into remission with thyroid and progesterone. Good interview discussing autoimmunity, approx 6 to 15-minute mark.
Interleukin 2, T cell receptor and sex hormone studies in autoimmune mice "This paper implicates gestational exposure of estrogen toward autoimmunity related to SLE" https://pubmed.ncbi.nlm.nih.gov/3112377/
Hypothyroidism and its Association with Systemic Lupus Erythematosus: A Cross Sectional Study in Chinese Patients https://doi.org/10.1016/j.amjms.2020.08.026